Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor ß modulators.

Peng, Xueke; Hu, Zhiye; Zhang, Jing; Ning, Wentao; Zhang, Silong; Dong, Chune; Shi, Xiaodong; Zhou, Hai-Bing

Peng, Xueke; Hu, Zhiye; Zhang, Jing; Ning, Wentao; Zhang, Silong; Dong, Chune; Shi, Xiaodong; Zhou, Hai-Bing.

Afiliação

Peng X; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, Ch
Hu Z; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, Ch
Zhang J; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, Ch
Ning W; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, Ch
Zhang S; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, Ch
Dong C; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, Ch
Shi X; Department of Chemistry, University of South Florida, Tampa, FL 33620-5250, USA. xmshi@usf.edu.
Zhou HB; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, Ch

Chem Commun (Camb) ; 55(97): 14570-14573, 2019 Dec 18.

Article em En | MEDLINE | ID: mdl-31660550

Assuntos

Antineoplásicos/farmacologia; Benzofuranos/química; Benzofuranos/farmacologia; Moduladores de Receptor Estrogênico/síntese química; Moduladores de Receptor Estrogênico/farmacologia; Receptor beta de Estrogênio/metabolismo; Antineoplásicos/síntese química; Antineoplásicos/química; Benzofuranos/síntese química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Moduladores de Receptor Estrogênico/química; Receptor alfa de Estrogênio/antagonistas & inibidores; Receptor alfa de Estrogênio/metabolismo; Receptor beta de Estrogênio/agonistas; Humanos; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofuranos / Moduladores de Receptor Estrogênico / Receptor beta de Estrogênio / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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