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Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.
Bott, Alex J; Shen, Jianliang; Tonelli, Claudia; Zhan, Le; Sivaram, Nithya; Jiang, Ya-Ping; Yu, Xufen; Bhatt, Vrushank; Chiles, Eric; Zhong, Hua; Maimouni, Sara; Dai, Weiwei; Velasquez, Stephani; Pan, Ji-An; Muthalagu, Nathiya; Morton, Jennifer; Anthony, Tracy G; Feng, Hui; Lamers, Wouter H; Murphy, Daniel J; Guo, Jessie Yanxiang; Jin, Jian; Crawford, Howard C; Zhang, Lanjing; White, Eileen; Lin, Richard Z; Su, Xiaoyang; Tuveson, David A; Zong, Wei-Xing.
Afiliação
  • Bott AJ; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA; Genetics Graduate Program, Stony Brook University, Stony Brook, NY 07794, USA.
  • Shen J; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
  • Tonelli C; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Zhan L; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
  • Sivaram N; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA; Northport VA Medical Center, Northport, NY 11768, USA.
  • Jiang YP; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA; Northport VA Medical Center, Northport, NY 11768, USA.
  • Yu X; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Bhatt V; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
  • Chiles E; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
  • Zhong H; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
  • Maimouni S; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
  • Dai W; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
  • Velasquez S; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
  • Pan JA; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
  • Muthalagu N; CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Morton J; CRUK Beatson Institute, Glasgow G61 1BD, UK.
  • Anthony TG; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
  • Feng H; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA.
  • Lamers WH; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Murphy DJ; CRUK Beatson Institute, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK.
  • Guo JY; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
  • Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Crawford HC; Departments of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Zhang L; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
  • White E; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
  • Lin RZ; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA; Northport VA Medical Center, Northport, NY 11768, USA.
  • Su X; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
  • Tuveson DA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Zong WX; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA. Electronic address: zongwx@rutgers.edu.
Cell Rep ; 29(5): 1287-1298.e6, 2019 10 29.
Article em En | MEDLINE | ID: mdl-31665640
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carbono / Glutamina / Nitrogênio Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carbono / Glutamina / Nitrogênio Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article