Introns: Good Day Junk Is Bad Day Treasure.
Trends Genet
; 35(12): 923-934, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31668856
ABSTRACT
Introns are ubiquitous in eukaryotic transcripts. They are often viewed as junk RNA but the huge energetic burden of transcribing, removing, and degrading them suggests a significant evolutionary advantage. Ostensibly, an intron functions within the host pre-mRNA to regulate its splicing, transport, and degradation. However, recent studies have revealed an entirely new class of trans-acting functions where the presence of intronic RNA in the cell impacts the expression of other genes in trans. Here, we review possible new mechanisms of intron functions, with a focus on the role of yeast introns in regulating the cell growth response to starvation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Íntrons
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Genoma
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Genômica
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article