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PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers.
Ali, Reem; Alabdullah, Muslim; Alblihy, Adel; Miligy, Islam; Mesquita, Katia A; Chan, Stephen Yt; Moseley, Paul; Rakha, Emad A; Madhusudan, Srinivasan.
Afiliação
  • Ali R; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham University Hospitals, Nottingham, NG5 1PB, UK.
  • Alabdullah M; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham University Hospitals, Nottingham, NG5 1PB, UK; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, NG51PB, UK.
  • Alblihy A; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham University Hospitals, Nottingham, NG5 1PB, UK.
  • Miligy I; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, NG51PB, UK.
  • Mesquita KA; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham University Hospitals, Nottingham, NG5 1PB, UK.
  • Chan SY; Department of Oncology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK.
  • Moseley P; Department of Oncology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK.
  • Rakha EA; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, NG51PB, UK.
  • Madhusudan S; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham University Hospitals, Nottingham, NG5 1PB, UK; Department of Oncology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK. Electronic address: srinivasan.mad
Cancer Lett ; 469: 124-133, 2020 01 28.
Article em En | MEDLINE | ID: mdl-31669203
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Resistencia a Medicamentos Antineoplásicos / Inibidores de Poli(ADP-Ribose) Polimerases / Proteína 1 Complementadora Cruzada de Reparo de Raio-X / Carcinoma Epitelial do Ovário Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Resistencia a Medicamentos Antineoplásicos / Inibidores de Poli(ADP-Ribose) Polimerases / Proteína 1 Complementadora Cruzada de Reparo de Raio-X / Carcinoma Epitelial do Ovário Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article