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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo.
Wortmann, Lars; Lindenthal, Bernhard; Muhn, Peter; Walter, Alexander; Nubbemeyer, Reinhard; Heldmann, Dieter; Sobek, Lothar; Morandi, Federica; Schrey, Anna K; Moosmayer, Dieter; Günther, Judith; Kuhnke, Joachim; Koppitz, Marcus; Lücking, Ulrich; Röhn, Ulrike; Schäfer, Martina; Nowak-Reppel, Katrin; Kühne, Ronald; Weinmann, Hilmar; Langer, Gernot.
Afiliação
  • Wortmann L; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Lindenthal B; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Muhn P; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Walter A; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Nubbemeyer R; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Heldmann D; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Sobek L; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Morandi F; Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle Strasse 10 , Campus Berlin-Buch, 13125 Berlin , Germany.
  • Schrey AK; Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle Strasse 10 , Campus Berlin-Buch, 13125 Berlin , Germany.
  • Moosmayer D; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Günther J; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Kuhnke J; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Koppitz M; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Lücking U; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Röhn U; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Schäfer M; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Nowak-Reppel K; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Kühne R; Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle Strasse 10 , Campus Berlin-Buch, 13125 Berlin , Germany.
  • Weinmann H; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
  • Langer G; Bayer AG, Research & Development, Pharmaceuticals , 13353 Berlin , Germany.
J Med Chem ; 62(22): 10321-10341, 2019 11 27.
Article em En | MEDLINE | ID: mdl-31670515
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores do LH / Estradiol / Naftiridinas Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores do LH / Estradiol / Naftiridinas Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article