C1-CBP-vancomycin: Impact of a Vancomycin C-Terminus Trimethylammonium Cation on Pharmacological Properties and Insights into Its Newly Introduced Mechanism of Action.

Wu, Zhi-Chen; Isley, Nicholas A; Okano, Akinori; Weiss, William J; Boger, Dale L

Wu, Zhi-Chen; Isley, Nicholas A; Okano, Akinori; Weiss, William J; Boger, Dale L.

Afiliação

Wu ZC; Department of Chemistry and Skaggs Institute for Chemical Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.
Isley NA; Department of Chemistry and Skaggs Institute for Chemical Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.
Okano A; Department of Chemistry and Skaggs Institute for Chemical Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.
Weiss WJ; University of North Texas System , College of Pharmacy , Fort Worth , Texas 76107 , United States.
Boger DL; Department of Chemistry and Skaggs Institute for Chemical Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.

J Org Chem ; 85(3): 1365-1375, 2020 02 07.

Article em En | MEDLINE | ID: mdl-31670958

Assuntos

Staphylococcus aureus Resistente à Meticilina; Vancomicina; Animais; Antibacterianos/farmacologia; Cátions; Humanos; Camundongos; Testes de Sensibilidade Microbiana; Vancomicina/farmacologia; Resistência a Vancomicina

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vancomicina / Staphylococcus aureus Resistente à Meticilina Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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