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Maternal Human Milk Oligosaccharide Profile Modulates the Impact of an Intervention with Iron and Galacto-Oligosaccharides in Kenyan Infants.
Paganini, Daniela; Uyoga, Mary A; Kortman, Guus A M; Boekhorst, Jos; Schneeberger, Sacha; Karanja, Simon; Hennet, Thierry; Zimmermann, Michael B.
Afiliação
  • Paganini D; Laboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland. daniela.paganini@uzh.ch.
  • Uyoga MA; Laboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland. mary.uyoga@hest.ethz.ch.
  • Kortman GAM; Department of Medical Epidemiology, College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, 00200 Nairobi, Kenya. mary.uyoga@hest.ethz.ch.
  • Boekhorst J; NIZO Food Research BV, 6718 ZB Ede, The Netherlands. Guus.Kortman@nizo.com.
  • Schneeberger S; NIZO Food Research BV, 6718 ZB Ede, The Netherlands. Jos.Boekhorst@nizo.com.
  • Karanja S; Department of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland. sacha.schneeberger@uzh.ch.
  • Hennet T; Department of Medical Epidemiology, College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, 00200 Nairobi, Kenya. skaranja@jkuat.ac.ke.
  • Zimmermann MB; Department of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland. thierry.hennet@uzh.ch.
Nutrients ; 11(11)2019 Oct 29.
Article em En | MEDLINE | ID: mdl-31671757
There is little data on human milk oligosaccharide (HMO) composition in Sub-Saharan Africa. Iron fortificants adversely affect the infant gut microbiota, while co-provision of prebiotic galacto-oligosaccharides (GOS) mitigates most of the adverse effects. Whether variations in maternal HMO profile can influence the infant response to iron and/or GOS fortificants is unknown. The aim of this study was to determine HMO profiles and the secretor/non-secretor phenotype of lactating Kenyan mothers and investigate their effects on the maternal and infant gut microbiota, and on the infant response to a fortification intervention with 5 mg iron (2.5 mg as sodium iron ethylenediaminetetraacetate and 2.5 mg as ferrous fumarate) and 7.5 g GOS. We studied mother-infant pairs (n = 80) participating in a 4-month intervention trial in which the infants (aged 6.5-9.5 months) received daily a micronutrient powder without iron, with iron or with iron and GOS. We assessed: (1) maternal secretor status and HMO composition; (2) effects of secretor status on the maternal and infant gut microbiota in a cross-sectional analysis at baseline of the intervention trial; and (3) interactions between secretor status and intervention groups during the intervention trial on the infant gut microbiota, gut inflammation, iron status, growth and infectious morbidity. Secretor prevalence was 72% and HMOs differed between secretors and non-secretors and over time of lactation. Secretor status did not predict the baseline composition of the maternal and infant gut microbiota. There was a secretor-status-by-intervention-group interaction on Bifidobacterium (p = 0.021), Z-scores for length-for-age (p = 0.022) and weight-for-age (p = 0.018), and soluble transferrin receptor (p = 0.041). In the no iron group, longitudinal prevalence of diarrhea was higher among infants of non-secretors (23.8%) than of secretors (10.4%) (p = 0.001). In conclusion, HMO profile may modulate the infant gut microbiota response to fortificant iron; compared to infants of secretor mothers, infants of non-secretor mothers may be more vulnerable to the adverse effect of iron but also benefit more from the co-provision of GOS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Micronutrientes / Suplementos Nutricionais / Ferro / Leite Humano Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Male País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Micronutrientes / Suplementos Nutricionais / Ferro / Leite Humano Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Male País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article