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Dopamine neuron ensembles signal the content of sensory prediction errors.
Stalnaker, Thomas A; Howard, James D; Takahashi, Yuji K; Gershman, Samuel J; Kahnt, Thorsten; Schoenbaum, Geoffrey.
Afiliação
  • Stalnaker TA; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
  • Howard JD; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
  • Takahashi YK; Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
  • Gershman SJ; Department of Psychology and Center for Brain Science, Harvard University, Cambridge, United States.
  • Kahnt T; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States.
  • Schoenbaum G; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, United States.
Elife ; 82019 11 01.
Article em En | MEDLINE | ID: mdl-31674910
ABSTRACT
Dopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a multidimensional prediction error. Yet such complexity is not evident in the activity of individual neurons or population averages. How then do downstream areas know what to learn in response to these signals? One possibility is that information about content is contained in the pattern of firing across many dopamine neurons. Consistent with this, here we show that the pattern of firing across a small group of dopamine neurons recorded in rats signals the identity of a mis-predicted sensory event. Further, this same information is reflected in the BOLD response elicited by sensory prediction errors in human midbrain. These data provide evidence that ensembles of dopamine neurons provide highly specific teaching signals, opening new possibilities for how this system might contribute to learning.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Potenciais de Ação / Mesencéfalo / Neurônios Dopaminérgicos / Aprendizagem Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Potenciais de Ação / Mesencéfalo / Neurônios Dopaminérgicos / Aprendizagem Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article