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In vivo effect of essential oil of Mentha x villosa and its active compound against Schistosoma mansoni (Sambon, 1907).
Matos-Rocha, T J; Cavalcanti, M G S; Veras, D L; Santos, A F; Freitas, C F de; Suassuna, A S C L; Melo, E S de; Barbosa-Filho, J M; Alves, L C; Santos, F A Brayner Dos.
Afiliação
  • Matos-Rocha TJ; Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
  • Cavalcanti MGS; Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
  • Veras DL; Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
  • Santos AF; Centro Universitário CESMAC, Programa de Pós-graduação em Análise de Sistemas Ambientais, Maceió, AL, Brasil.
  • Freitas CF; Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
  • Suassuna ASCL; Universidade Federal da Paraíba, João Pessoa, PA, Brasil.
  • Melo ES; Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
  • Barbosa-Filho JM; Universidade Federal da Paraíba, João Pessoa, PA, Brasil.
  • Alves LC; Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
  • Santos FABD; Departamento de Parasitologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
Braz J Biol ; 80(3): 582-588, 2020 Sep.
Article em En | MEDLINE | ID: mdl-31691742
Schistosomiasis treatment is dependent on a single drug, praziquantel (PZQ). The development of resistance of PZQ has drawn the attention of many researchers to alternative drugs. One viable and promising treatment is the study of medicinal plants as a new approach to the experimental treatment for Schistosomiasis. The present work aimed to evaluate in vivo antischistosomal activity of effect of Mentha x villosa Oil Essential (Mv-EO) and rotundifolone (ROT) against Schistosoma mansoni. Thirty-day-old female Swiss webster mice (Mus musculus) weighing 50 grams were used. Mice were infected with 80 cercariae of S. mansoni (BH strain) and orally administered Mv-EO (50, 100 and 200 mg/Kg) and ROT (35.9, 70.9 and 141.9 mg/Kg) at 45-days post infection for 5 consecutive days. All mice were euthanized 60 days after infection. Praziquantel was the positive control in the experiment. Doses of 200 mg/kg (Mv-EO) and ROT (141.9 mg/Kg) resulted in a significant reduction in fluke burden (72.44% and 74.48%, respectively). There was also marked reduction in liver, intestinal and faecal and changed oogram pattern, compared to infected untreated mice. Considering the results obtained, further biological studies are required in order to elucidate the mechanism of schistosomicidal action on against adult S. mansoni.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni / Óleos Voláteis / Mentha Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni / Óleos Voláteis / Mentha Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article