Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis.
Analyst
; 144(24): 7270-7277, 2019 Dec 02.
Article
em En
| MEDLINE
| ID: mdl-31693024
ABSTRACT
Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The utility of these improved pulse sequences is demonstrated in a metabolomic study of multiple sclerosis (MS) patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Análise Química do Sangue
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Água
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Espectroscopia de Ressonância Magnética
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Substâncias Macromoleculares
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article