Total Synthesis of (+)-6-epi-Ophiobolinâ
A.
Angew Chem Int Ed Engl
; 59(4): 1532-1536, 2020 01 20.
Article
em En
| MEDLINE
| ID: mdl-31693792
ABSTRACT
The ophiobolin sesterterpenes are notable plant pathogens which have recently elicited significant chemical and biological attention because of their intriguing carbogenic frameworks, reactive functionalities, and emerging anticancer profiles. Reported herein is a total synthesis of (+)-6-epi-ophiobolinâ
A in 14 steps, a task which addresses construction of the synthetically challenging spirocyclic tetrahydrofuran motif as well as several other key stereochemical problems. This work demonstrates a streamlined synthetic platform to complex ophiobolins leveraging disparate termination modes of a radical polycyclization cascade for divergent elaboration and functionalization.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Sesterterpenos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article