SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating <i>Akt1</i> and <i>mTOR</i> transcription.

Zhang, Tuo; Du, Xinhua; Zhao, Lihua; He, Meina; Lin, Lin; Guo, Chuanhui; Zhang, Xinran; Han, Jun; Yan, Hao; Huang, Kun; Sun, Guanghong; Yan, Lei; Zhou, Bo; Xia, Guoliang; Qin, YingYing; Wang, Chao

SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription.

Zhang, Tuo; Du, Xinhua; Zhao, Lihua; He, Meina; Lin, Lin; Guo, Chuanhui; Zhang, Xinran; Han, Jun; Yan, Hao; Huang, Kun; Sun, Guanghong; Yan, Lei; Zhou, Bo; Xia, Guoliang; Qin, YingYing; Wang, Chao.

Afiliação

Zhang T; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Du X; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhao L; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
He M; Department of Pathology and Hepatology, The 5th Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
Lin L; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Guo C; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhang X; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Han J; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Yan H; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Huang K; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Sun G; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Yan L; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhou B; Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Xia G; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.
Qin Y; The Key Laboratory of Reproductive Endocrinology, Shandong University, Ministry of Education, Jinan, China.
Wang C; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.

FASEB J ; 33(12): 14703-14716, 2019 12.

Article em En | MEDLINE | ID: mdl-31693862

Assuntos

Folículo Ovariano/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Sirtuína 1/metabolismo; Serina-Treonina Quinases TOR/genética; Ativação Transcricional; Animais; Células Cultivadas; Feminino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos ICR; Camundongos Endogâmicos NOD; Camundongos SCID; Folículo Ovariano/citologia; Regiões Promotoras Genéticas; Ligação Proteica; Proteínas Proto-Oncogênicas c-akt/metabolismo; Sirtuína 1/genética; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

in vitro activation; ovary; primordial follicle activation; resveratrol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Transcricional / Proteínas Proto-Oncogênicas c-akt / Sirtuína 1 / Serina-Treonina Quinases TOR / Folículo Ovariano Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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