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Bevacizumab for optic pathway glioma with worsening visual field in absence of imaging progression: 2 case reports and literature review.
Yamasaki, Fumiyuki; Takano, Motoki; Yonezawa, Ushio; Taguchi, Akira; Kolakshyapati, Manish; Okumichi, Hideaki; Kiuchi, Yoshiaki; Kurisu, Kaoru.
Afiliação
  • Yamasaki F; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. fyama@hiroshima-u.ac.jp.
  • Takano M; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Yonezawa U; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Taguchi A; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Kolakshyapati M; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Okumichi H; Department of Neuroscience, B&B Hospital, Gwarko, Lalitpur, Nepal.
  • Kiuchi Y; Department of Ophthalmology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Kurisu K; Department of Ophthalmology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Childs Nerv Syst ; 36(3): 635-639, 2020 03.
Article em En | MEDLINE | ID: mdl-31701281
ABSTRACT
Children with optic pathway gliomas (OPGs) frequently suffer from problems of visual function resulting from tumors. Previous reports showed that bevacizumab improved visual function in patients with OPG via tumor response to treatment. In these two case reports, we show that bevacizumab improved visual field without tumor response as seen in imaging. Both, a 10-year-old girl and a 6-year-old boy, had previous history of treatment with platinum-based chemotherapy. They had visual deterioration without tumor progression on MR imaging. Bevacizumab effectively and immediately improved visual field in both patients without imaging response of OPG. We emphasize that bevacizumab should be considered for patients with OPGs having visual deterioration without tumor progression.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neurofibromatose 1 / Glioma do Nervo Óptico Tipo de estudo: Observational_studies Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neurofibromatose 1 / Glioma do Nervo Óptico Tipo de estudo: Observational_studies Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article