Liraglutide improves lipid metabolism by enhancing cholesterol efflux associated with ABCA1 and ERK1/2 pathway.

Wu, Ya-Ru; Shi, Xiao-Yun; Ma, Chun-Yan; Zhang, Yue; Xu, Rui-Xia; Li, Jian-Jun

Wu, Ya-Ru; Shi, Xiao-Yun; Ma, Chun-Yan; Zhang, Yue; Xu, Rui-Xia; Li, Jian-Jun.

Afiliação

Wu YR; Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Shi XY; Division of Endocrinology, Beijing Chaoyang Integrative Medicine Emergency Medical Center, Beijing, 100022, China.
Ma CY; Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Zhang Y; Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Xu RX; Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. ruixiaxu@sina.com.
Li JJ; Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. lijianjun@126.com.

Cardiovasc Diabetol ; 18(1): 146, 2019 11 09.

Article em En | MEDLINE | ID: mdl-31706303

Assuntos

Transportador 1 de Cassete de Ligação de ATP/metabolismo; Colesterol/sangue; Diabetes Mellitus/tratamento farmacológico; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Hepatócitos/efeitos dos fármacos; Hipoglicemiantes/farmacologia; Incretinas/farmacologia; Liraglutida/farmacologia; Fígado/efeitos dos fármacos; Transportador 1 de Cassete de Ligação de ATP/genética; Animais; Glicemia/efeitos dos fármacos; Glicemia/metabolismo; Diabetes Mellitus/sangue; Diabetes Mellitus/enzimologia; Dieta Hiperlipídica; Modelos Animais de Doenças; Células Hep G2; Hepatócitos/enzimologia; Humanos; Fígado/enzimologia; Masculino; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; Fosforilação; Transdução de Sinais

Palavras-chave

ABCA1; High glucose; High-fat diet; Liraglutide; Molecular mechanism; Reverse cholesterol transport; db/db mice

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colesterol / Hepatócitos / MAP Quinases Reguladas por Sinal Extracelular / Diabetes Mellitus / Incretinas / Transportador 1 de Cassete de Ligação de ATP / Liraglutida / Hipoglicemiantes / Fígado Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google