Melanoma in a cohort of organ transplant recipients: Experience from a dedicated transplant dermatology clinic in Victoria, Australia.
J Am Acad Dermatol
; 83(3): 773-779, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-31706934
ABSTRACT
BACKGROUND:
There is limited information on the profile of melanomas diagnosed in a specialist transplant dermatology clinic.OBJECTIVE:
To describe the incidence and characteristics of incident primary melanomas in a cohort of organ transplant recipients (OTRs) attending a specialized transplant dermatology clinic and determine the number of pigmented lesions needed to excise for every melanoma diagnosed.METHODS:
A retrospective study of 327 OTRs monitored by an Australian clinic during a 10-year period.RESULTS:
There were 11 incident melanomas diagnosed during a total follow-up of 1280 patient-years. The mean interval between the first transplant and diagnosis was 5.5 years. Only 2 melanomas were >1 mm in Breslow thickness. Seven melanomas (64%) arose de novo. A contiguous nevus was present in 4 cases. Metastatic disease did not develop in the melanoma patients during the follow-up period, and all remain alive. The needed to excise for every melanoma diagnosed ratio was 161.LIMITATIONS:
The crude incidence rates were age standardized, unlike the comparison rates of melanoma in the general population, and the cohort was small.CONCLUSION:
Most melanomas diagnosed in OTR patients attending a specialized transplant dermatology service were detected early. Our data suggest early detection may reduce the proportion of OTRs presenting with thick melanomas, thus improving prognosis and patient outcomes. A needed to excise for every melanoma diagnosed ratio of 161 is not unreasonable for this cohort of high-risk patients. To our knowledge, this is the first time this ratio has been calculated for a cohort of OTRs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Transplante de Órgãos
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Procedimentos Cirúrgicos Dermatológicos
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Transplantados
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Melanoma
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Oceania
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article