Granzyme A Participates in the Pathogenesis of Infection-Associated Acute Encephalopathy.
J Child Neurol
; 35(3): 208-214, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31709864
ABSTRACT
OBJECTIVE:
The present study aimed to determine whether granzymes are implicated in the pathogenesis of infection-associated acute encephalopathy (AE).METHODS:
We investigated granzyme and cytokine levels in the cerebrospinal fluid of patients with acute encephalopathy or complex febrile seizures (cFS). A total of 24 acute encephalopathy patients and 22 complex febrile seizures patients were included in the present study. Levels of granzymes A and B were measured using enzyme-linked immunosorbent assay, and levels of tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ), interleukin 1ß (IL-1ß), IL-1 receptor antagonist (IL-1RA), IL-4, IL-6, IL-8, and IL-10 were assessed using the Bio-Plex suspension array system.RESULTS:
Cerebrospinal fluid levels of granzyme A were significantly higher, and those of TNF-α and IL-1RA were significantly lower in the AE group than in the cFS group; however, no significant differences in the levels of granzyme B, IFN-γ, IL-1ß, IL-4, IL-6, IL-8, and IL-10 were observed between the 2 groups. In addition, no significant differences in granzyme A, granzyme B, or cytokine levels were observed between acute encephalopathy patients with and those without neurologic sequelae.CONCLUSIONS:
Our findings indicate the involvement of granzyme A in the pathogenesis of acute encephalopathy.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
Granzimas
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
Limite:
Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article