An integrative framework for perceptual disturbances in psychosis.
Nat Rev Neurosci
; 20(12): 763-778, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31712782
ABSTRACT
Perceptual disturbances in psychosis, such as auditory verbal hallucinations, are associated with increased baseline activity in the associative auditory cortex and increased dopamine transmission in the associative striatum. Perceptual disturbances are also associated with perceptual biases that suggest increased reliance on prior expectations. We review theoretical models of perceptual inference and key supporting physiological evidence, as well as the anatomy of associative cortico-striatal loops that may be relevant to auditory perceptual inference. Integrating recent findings, we outline a working framework that bridges neurobiology and the phenomenology of perceptual disturbances via theoretical models of perceptual inference.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Dopamina
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Córtex Cerebral
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Corpo Estriado
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Alucinações
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Rede Nervosa
Tipo de estudo:
Prognostic_studies
/
Qualitative_research
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article