Vibrational Dynamics of Carbamazepine: Studies Based on Two-Dimensional Correlation Spectroscopy and X-ray Diffraction.
Appl Spectrosc
; 74(4): 473-484, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31718245
ABSTRACT
Fourier transform infrared spectroscopy as well as X-ray diffraction (XRD) were employed to thoroughly study phase transitions taking place during heating-cooling-heating cycle of carbamazepine (CBZ), a well known and commonly used antiepileptic drug. Both techniques revealed cold crystallization taking place during second heating. Moreover, XRD studies for the first time proved the coexistence of CBZ (form I) and iminostilbene (product of the degradation of CBZ) after a heating-cooling cycle. Moving window two-dimensional correlation (MW 2D-COS) spectroscopy and two-dimensional correlation spectroscopy were shown to be effective tools to reveal phase sequences and to provide information about the order of sequential changes of bands' intensities during each phase transition, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Carbamazepina
/
Dibenzazepinas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article