Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent.
J Pharm Biomed Anal
; 179: 112961, 2020 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-31732404
ABSTRACT
Herein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Transmission Electron Microscopy (TEM), UV-vis spectrophotometer, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). According to TEM analysis, Pt nanoparticles have spherical shapes and sizes between 1-6â¯nm. Moreover, the biogenic Pt NPs was assessed for its cytotoxicity effect on MDA-MB-231 breast and HeLa cervical cancer lines and their antibacterial effect against selected strains of gram-positive and negative bacteria. The cytotoxicity and bacterial tests showed the effectiveness of biogenic Pt nanoparticles. Dose-dependent toxicity effects were shown in the MDA-MB-231 breast and HeLa cervical cancer lines (IC50 36.86⯵g/mL and 19.83⯵g/mL, respectively). In addition, Pt NPs showed high zone diameters against gram-positive and gram-negative bacteria at concentrations of 100 and 500⯵g/ml. These results contribute to the development of the pharmaceutical industry as a potential antibacterial and anticancer agent.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Nigella sativa
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Antibacterianos
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Antineoplásicos Fitogênicos
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article