Inhibition of CD44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy.

Wu, Po-Ting; Su, Wei-Ren; Li, Chia-Lung; Hsieh, Jeng-Long; Ma, Ching-Hou; Wu, Chao-Liang; Kuo, Li-Chieh; Jou, I-Ming; Chen, Shih-Yao

Wu, Po-Ting; Su, Wei-Ren; Li, Chia-Lung; Hsieh, Jeng-Long; Ma, Ching-Hou; Wu, Chao-Liang; Kuo, Li-Chieh; Jou, I-Ming; Chen, Shih-Yao.

Afiliação

Wu PT; Department of Orthopaedics, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Su WR; Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Li CL; Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan, Taiwan.
Hsieh JL; Department of Orthopaedics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan.
Ma CH; Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan.
Wu CL; Department of Orthopaedics, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuo LC; Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jou IM; Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chen SY; Department of Orthopaedics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan.

J Biol Chem ; 294(52): 20177-20184, 2019 12 27.

Article em En | MEDLINE | ID: mdl-31732563

Assuntos

Apoptose; Receptores de Hialuronatos/metabolismo; Mediadores da Inflamação/metabolismo; Metaloproteinases da Matriz/metabolismo; Actinas/genética; Actinas/metabolismo; Animais; Anticorpos/imunologia; Apoptose/efeitos dos fármacos; Células Cultivadas; Ciclo-Oxigenase 2/genética; Ciclo-Oxigenase 2/metabolismo; Humanos; Receptores de Hialuronatos/genética; Receptores de Hialuronatos/imunologia; Masculino; Metaloproteinases da Matriz/genética; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Dióxido de Silício/toxicidade; Tendinopatia/metabolismo; Tendinopatia/patologia; Tenócitos/citologia; Tenócitos/metabolismo; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

CD44; apoptosis; cytokine induction; inflammation; matrix metalloproteinase (MMP); tendinopathy; tendon

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Mediadores da Inflamação / Receptores de Hialuronatos / Metaloproteinases da Matriz Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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