Interferon Gamma Reprograms Host Mitochondrial Metabolism through Inhibition of Complex II To Control Intracellular Bacterial Replication.

Jessop, Forrest; Buntyn, Robert; Schwarz, Benjamin; Wehrly, Tara; Scott, Dana; Bosio, Catharine M

Jessop, Forrest; Buntyn, Robert; Schwarz, Benjamin; Wehrly, Tara; Scott, Dana; Bosio, Catharine M.

Afiliação

Jessop F; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Buntyn R; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Schwarz B; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Wehrly T; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Scott D; Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Bosio CM; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA bosioc@niaid.nih.gov.

Infect Immun ; 88(2)2020 01 22.

Article em En | MEDLINE | ID: mdl-31740527

Assuntos

Francisella tularensis/efeitos dos fármacos; Interferon gama/farmacologia; Mitocôndrias/efeitos dos fármacos; Animais; Membrana Celular/metabolismo; Membrana Celular/microbiologia; Citosol/metabolismo; Citosol/microbiologia; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Mitocôndrias/metabolismo; Mitocôndrias/microbiologia; Espécies Reativas de Nitrogênio/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Succinatos/farmacologia; Tularemia/tratamento farmacológico; Tularemia/metabolismo; Tularemia/microbiologia

Palavras-chave

Francisella tularensis; IFN-Î³; macrophages; mitochondrial metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferon gama / Francisella tularensis / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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