Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

Tian, E; Wang, Shengjun; Zhang, Liping; Zhang, Ying; Malicdan, May C; Mao, Yang; Christoffersen, Christina; Tabak, Lawrence A; Schjoldager, Katrine T; Ten Hagen, Kelly G

Tian, E; Wang, Shengjun; Zhang, Liping; Zhang, Ying; Malicdan, May C; Mao, Yang; Christoffersen, Christina; Tabak, Lawrence A; Schjoldager, Katrine T; Ten Hagen, Kelly G.

Afiliação

Tian E; Developmental Glycobiology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, MD 20892-4370.
Wang S; School of Pharmaceutical Sciences, Sun Yat-sen University, 510006 Guangzhou, China.
Zhang L; Developmental Glycobiology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, MD 20892-4370.
Zhang Y; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908.
Malicdan MC; Undiagnosed Diseases Program, Office of the Clinical Director, National Human Genome Research Institute (NHGRI), National Institutes of Health, Bethesda, MD 20892.
Mao Y; School of Pharmaceutical Sciences, Sun Yat-sen University, 510006 Guangzhou, China.
Christoffersen C; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Tabak LA; Department of Biomedical Sciences, Rigshospitalet, University of Copenhagen, 2200 Copenhagen, Denmark.
Schjoldager KT; Section on Biological Chemistry, NIDCR, National Institutes of Health, Bethesda, MD 20892-4370.
Ten Hagen KG; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

Proc Natl Acad Sci U S A ; 116(50): 25196-25202, 2019 12 10.

Article em En | MEDLINE | ID: mdl-31740596

Assuntos

Rim/fisiopatologia; Proteína-2 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo; N-Acetilgalactosaminiltransferases/metabolismo; Insuficiência Renal Crônica/metabolismo; alfa-Globulinas/genética; alfa-Globulinas/metabolismo; Animais; Endocitose; Feminino; Glicosilação; Humanos; Rim/metabolismo; Túbulos Renais Proximais/metabolismo; Ligantes; Proteína-2 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética; Masculino; Camundongos; Camundongos Knockout; N-Acetilgalactosaminiltransferases/genética; Ligação Proteica; Insuficiência Renal Crônica/genética; Insuficiência Renal Crônica/fisiopatologia; Proteína de Ligação a Vitamina D/genética; Proteína de Ligação a Vitamina D/metabolismo

Palavras-chave

GALNT11; O-glycosylation; kidney disease; megalin; proteinuria

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: N-Acetilgalactosaminiltransferases / Proteína-2 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Insuficiência Renal Crônica / Rim Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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