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One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD).
Cunningham, Steve; Graham, Catriona; MacLean, Morag; Aurora, Paul; Ashworth, Michael; Barbato, Angelo; Calder, Alistair; Carlens, Julia; Clement, Annick; Hengst, Meike; Kammer, Birgit; Kiper, Nural; Krenke, Katarzyna; Kronfeld, Kai; Lange, Joanna; Ley-Zaporozhan, Julia; Nicholson, Andrew G; Reu, Simone; Wesselak, Traudl; Wetzke, Martin; Bush, Andrew; Schwerk, Nicolaus; Griese, Matthias.
Afiliação
  • Cunningham S; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK steve.cunningham@nhs.net.
  • Graham C; Department of Respiratory and Sleep Medicine, Royal Hospital for Sick Children, Edinburgh, UK.
  • MacLean M; Wellcome Trust Clinical Research Facility, Western General Hospital, Edinburgh, UK.
  • Aurora P; Edinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK.
  • Ashworth M; Department of Respiratory Paediatrics, Great Ormond Street Hospital, London, UK.
  • Barbato A; Department of Paediatric Pathology, Great Ormond Street Hospital for Children NHS Trust, London, UK.
  • Calder A; Department of Women's and Children's Health, University of Padova, Padua, Italy.
  • Carlens J; Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Clement A; Department of Pediatric Pneumology, Medizinische Hochschule Hannover, Hannover, Germany.
  • Hengst M; Paediatric Pulmonary Department, Trousseau Hospital APHP, Sorbonne Universities and Pierre et Marie Curie University, Paris, France.
  • Kammer B; Pediatric Pneumology, Hauner Children's University Hospital, Munich, Germany.
  • Kiper N; University Children's Hospital at Dr. von Haunersches Kinderspital, LMU Munich, Munich, Germany.
  • Krenke K; Pediatric Pulmonology, Hacettepe University, Ankara, Turkey.
  • Kronfeld K; Department of Pediatric Pneumology and Allergy, Warszawski Uniwersytet Medyczny, Warszawa, Poland.
  • Lange J; IZKS Mainz, University Medical Center Mainz, Mainz, Germany.
  • Ley-Zaporozhan J; Department of Pediatric Pneumology and Allergy, Warszawski Uniwersytet Medyczny, Warszawa, Poland.
  • Nicholson AG; Institute for Clinical Radiology, University Hospital of Ludwig Maximilian University, Munich, Germany.
  • Reu S; Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.
  • Wesselak T; Pathology, Ludwig-Maximilians-Universitat Munchen Medizinische Fakultat, Munchen, Germany.
  • Wetzke M; Pediatric Pneumology, Hauner Children's University Hospital, Munich, Germany.
  • Bush A; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
  • Schwerk N; Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK.
  • Griese M; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Thorax ; 75(2): 172-175, 2020 02.
Article em En | MEDLINE | ID: mdl-31748256
ABSTRACT
We performed a prospective, observational, cohort study of children newly diagnosed with children's interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3-7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO2) median 92% (IQR 88-96). Death (n=20, 16%) was the most common in those <6 months of age with SpO2<94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8-12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corticosteroides / Doenças Pulmonares Intersticiais / Azitromicina / Hidroxicloroquina Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Corticosteroides / Doenças Pulmonares Intersticiais / Azitromicina / Hidroxicloroquina Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article