Your browser doesn't support javascript.
loading
A major role for common genetic variation in anxiety disorders.
Purves, Kirstin L; Coleman, Jonathan R I; Meier, Sandra M; Rayner, Christopher; Davis, Katrina A S; Cheesman, Rosa; Bækvad-Hansen, Marie; Børglum, Anders D; Wan Cho, Shing; Jürgen Deckert, J; Gaspar, Héléna A; Bybjerg-Grauholm, Jonas; Hettema, John M; Hotopf, Matthew; Hougaard, David; Hübel, Christopher; Kan, Carol; McIntosh, Andrew M; Mors, Ole; Bo Mortensen, Preben; Nordentoft, Merete; Werge, Thomas; Nicodemus, Kristin K; Mattheisen, Manuel; Breen, Gerome; Eley, Thalia C.
Afiliação
  • Purves KL; King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Coleman JRI; King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Meier SM; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Rayner C; Child and Adolescent Mental Health Centre-Mental Health Services Capital Region, Copenhagen Region, Denmark.
  • Davis KAS; Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
  • Cheesman R; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
  • Bækvad-Hansen M; King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Børglum AD; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Wan Cho S; King's College London; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Jürgen Deckert J; King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Gaspar HA; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
  • Bybjerg-Grauholm J; Danish Centre for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
  • Hettema JM; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
  • Hotopf M; Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
  • Hougaard D; Centre for integrative Sequencing (iSEQ), Aarhus University, Aarhus C, Denmark.
  • Hübel C; King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Kan C; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
  • McIntosh AM; King's College London; Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Mors O; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Bo Mortensen P; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
  • Nordentoft M; Danish Centre for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
  • Werge T; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
  • Nicodemus KK; NIHR Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
  • Mattheisen M; King's College London; Institute of Psychiatry, Psychology & Neuroscience, London, UK.
  • Breen G; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
  • Eley TC; Danish Centre for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Mol Psychiatry ; 25(12): 3292-3303, 2020 12.
Article em En | MEDLINE | ID: mdl-31748690
ABSTRACT
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article