Simultaneous determination of urinary 31 metabolites of VOCs, 8-hydroxy-2'-deoxyguanosine, and trans-3'-hydroxycotinine by UPLC-MS/MS: <sup>13</sup>C- and <sup>15</sup>N-labeled isotoped internal standards are more effective on reduction of matrix effect.

Kuang, Hongxuan; Li, Yonghong; Jiang, Wenhui; Wu, Peiqiong; Tan, Jianhua; Zhang, Haibin; Pang, Qihua; Ma, Shengtao; An, Taicheng; Fan, Ruifang

Simultaneous determination of urinary 31 metabolites of VOCs, 8-hydroxy-2'-deoxyguanosine, and trans-3'-hydroxycotinine by UPLC-MS/MS: ¹³C- and ¹⁵N-labeled isotoped internal standards are more effective on reduction of matrix effect.

Kuang, Hongxuan; Li, Yonghong; Jiang, Wenhui; Wu, Peiqiong; Tan, Jianhua; Zhang, Haibin; Pang, Qihua; Ma, Shengtao; An, Taicheng; Fan, Ruifang.

Afiliação

Kuang H; Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School of Life Sciences, South China Normal University, Guangzhou, 510631, Guangdong, China.
Li Y; Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School of Life Sciences, South China Normal University, Guangzhou, 510631, Guangdong, China.
Jiang W; Guangzhou Women and Children's Medical Center, Guangzhou, 510120, Guangdong, China.
Wu P; Guangzhou Women and Children's Medical Center, Guangzhou, 510120, Guangdong, China.
Tan J; Guangzhou Quality Supervision and Testing Institute, Guangzhou, 511447, Guangdong, China.
Zhang H; Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School of Life Sciences, South China Normal University, Guangzhou, 510631, Guangdong, China.
Pang Q; Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School of Life Sciences, South China Normal University, Guangzhou, 510631, Guangdong, China.
Ma S; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangz
An T; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangz
Fan R; Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School of Life Sciences, South China Normal University, Guangzhou, 510631, Guangdong, China. 20001047@m.scnu.edu.cn.

Anal Bioanal Chem ; 411(29): 7841-7855, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31748896

Assuntos

8-Hidroxi-2'-Desoxiguanosina/urina; Cromatografia Líquida/métodos; Cotinina/análogos & derivados; Espectrometria de Massas em Tandem/métodos; Compostos Orgânicos Voláteis/urina; 8-Hidroxi-2'-Desoxiguanosina/normas; Estudos de Casos e Controles; Cotinina/normas; Cotinina/urina; Humanos; Isótopos de Nitrogênio; Padrões de Referência; Fumar/urina; Compostos Orgânicos Voláteis/normas

Palavras-chave

DNA damage; Matrix effect; Passive smoking; Urinary metabolites; Volatile organic compounds

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Cotinina / Espectrometria de Massas em Tandem / Compostos Orgânicos Voláteis / 8-Hidroxi-2'-Desoxiguanosina Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google