Neogenin-1 distinguishes between myeloid-biased and balanced <i>Hoxb5</i><sup>+</sup> mouse long-term hematopoietic stem cells.

Gulati, Gunsagar S; Zukowska, Monika; Noh, Joseph J; Zhang, Allison; Wesche, Daniel J; Sinha, Rahul; George, Benson M; Weissman, Irving L; Szade, Krzysztof

Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5⁺ mouse long-term hematopoietic stem cells.

Gulati, Gunsagar S; Zukowska, Monika; Noh, Joseph J; Zhang, Allison; Wesche, Daniel J; Sinha, Rahul; George, Benson M; Weissman, Irving L; Szade, Krzysztof.

Afiliação

Gulati GS; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Zukowska M; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Noh JJ; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387, Krakow, Poland.
Zhang A; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Wesche DJ; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Sinha R; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
George BM; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Weissman IL; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Szade K; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305; irv@stanford.edu krzysztof.szade@uj.edu.pl.

Proc Natl Acad Sci U S A ; 116(50): 25115-25125, 2019 12 10.

Article em En | MEDLINE | ID: mdl-31754028

Assuntos

Células-Tronco Hematopoéticas/metabolismo; Células-Tronco Hematopoéticas/fisiologia; Proteínas de Homeodomínio/metabolismo; Proteínas de Membrana/metabolismo; Envelhecimento; Animais; Feminino; Transplante de Células-Tronco Hematopoéticas; Proteínas de Homeodomínio/genética; Proteínas de Membrana/genética; Camundongos; Camundongos Transgênicos

Palavras-chave

Neogenin-1; aging; hematopoietic stem cell; myeloid bias; transplantation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Proteínas de Homeodomínio / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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