High Compared with Moderate Protein Intake Reduces Adaptive Thermogenesis and Induces a Negative Energy Balance during Long-term Weight-Loss Maintenance in Participants with Prediabetes in the Postobese State: A PREVIEW Study.
J Nutr
; 150(3): 458-463, 2020 03 01.
Article
em En
| MEDLINE
| ID: mdl-31754687
ABSTRACT
BACKGROUND:
Weight loss has been associated with adaptations in energy expenditure. Identifying factors that counteract these adaptations are important for long-term weight loss and weight maintenance.OBJECTIVE:
The aim of this study was to investigate whether increased protein/carbohydrate ratio would reduce adaptive thermogenesis (AT) and the expected positive energy balance (EB) during weight maintenance after weight loss in participants with prediabetes in the postobese state.METHODS:
In 38 participants, the effects of 2 diets differing in protein/carbohydrate ratio on energy expenditure and respiratory quotient (RQ) were assessed during 48-h respiration chamber measurements â¼34 mo after weight loss. Participants consumed a high-protein (HP) diet (n = 20; 13 women/7 men; age 64.0 ± 6.2 y; BMI 28.9 ± 4.0 kg/m 2) with 254530% or a moderate-protein (MP) diet (n = 18; 9 women/9 men; age 65.1 ± 5.8 y; BMI 29.0 ± 3.8 kg/m 2) with 155530% of energy from proteincarbohydratefat. Predicted resting energy expenditure (REEp) was calculated based on fat-free mass and fat mass. AT was assessed by subtracting measured resting energy expenditure (REE) from REEp. The main outcomes included differences in components of energy expenditure, substrate oxidation, and AT between groups.RESULTS:
EB (MP = 0.2 ± 0.9 MJ/d; HP = -0.5 ± 0.9 MJ/d) and RQ (MP = 0.84 ± 0.02; HP = 0.82 ± 0.02) were reduced and REE (MP 7.3 ± 0.2 MJ/d compared with HP 7.8 ± 0.2 MJ/d) was increased in the HP group compared with the MP group (P < 0.05). REE was not different from REEp in the HP group, whereas REE was lower than REEp in the MP group (P < 0.05). Furthermore, EB was positively related to AT (rs = 0.74; P < 0.001) and RQ (rs = 0.47; P < 0.01) in the whole group of participants.CONCLUSIONS:
In conclusion, an HP diet compared with an MP diet led to a negative EB and counteracted AT â¼34 mo after weight loss, in participants with prediabetes in the postobese state. These results indicate the relevance of compliance to an increased protein/carbohydrate ratio for long-term weight maintenance after weight loss. The trial was registered at clinicaltrials.gov as NCT01777893.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
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Proteínas Alimentares
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Redução de Peso
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Termogênese
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Metabolismo Energético
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article