Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto <i>HOX</i> clusters causing aberrant <i>HOX</i> expression in leukemia cells.

Oka, Masahiro; Mura, Sonoko; Otani, Mayumi; Miyamoto, Yoichi; Nogami, Jumpei; Maehara, Kazumitsu; Harada, Akihito; Tachibana, Taro; Yoneda, Yoshihiro; Ohkawa, Yasuyuki

Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells.

Oka, Masahiro; Mura, Sonoko; Otani, Mayumi; Miyamoto, Yoichi; Nogami, Jumpei; Maehara, Kazumitsu; Harada, Akihito; Tachibana, Taro; Yoneda, Yoshihiro; Ohkawa, Yasuyuki.

Afiliação

Oka M; Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan.
Mura S; Laboratory of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Otani M; Biomolecular Dynamics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Miyamoto Y; Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan.
Nogami J; Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan.
Maehara K; Department of Advanced Medical Initiatives, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Harada A; Department of Advanced Medical Initiatives, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Tachibana T; Department of Advanced Medical Initiatives, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Yoneda Y; Department of Bioengineering, Graduate School of Engineering, Osaka City University, Osaka, Japan.
Ohkawa Y; Laboratory of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

Elife ; 82019 11 22.

Article em En | MEDLINE | ID: mdl-31755865

Assuntos

Carioferinas/genética; Leucemia Mieloide Aguda/genética; Complexo de Proteínas Formadoras de Poros Nucleares/genética; Proteínas Nucleares/genética; Receptores Citoplasmáticos e Nucleares/genética; Transporte Ativo do Núcleo Celular/genética; Linhagem Celular Tumoral; Núcleo Celular/genética; Cromatina/genética; Citoplasma/genética; Proteínas de Ligação a DNA/genética; Regulação Leucêmica da Expressão Gênica/genética; Chaperonas de Histonas/genética; Proteínas de Homeodomínio/genética; Humanos; Leucemia Mieloide Aguda/patologia; Mutação/genética; Sinais de Exportação Nuclear/genética; Nucleofosmina; Proteína Exportina 1

Palavras-chave

CRM1; HOX cluster; NPM1c; SET-Nup214; cell biology; chromosomes; gene expression; human; leukemia; nucleoporin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Leucemia Mieloide Aguda / Receptores Citoplasmáticos e Nucleares / Carioferinas / Complexo de Proteínas Formadoras de Poros Nucleares Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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