The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Sapkota, Madhab; Marreddy, Ravi K R; Wu, Xiaoqian; Kumar, Manish; Hurdle, Julian G

Sapkota, Madhab; Marreddy, Ravi K R; Wu, Xiaoqian; Kumar, Manish; Hurdle, Julian G.

Afiliação

Sapkota M; University of Texas at Arlington, Department of Biology, Arlington, TX, 76019, United States.
Marreddy RKR; Texas A & M University Health Science Center, Biosciences and Technology, Houston, TX, 77030, United States.
Wu X; Texas A & M University Health Science Center, Biosciences and Technology, Houston, TX, 77030, United States.
Kumar M; University of Texas at Arlington, Department of Biology, Arlington, TX, 76019, United States.
Hurdle JG; Texas A & M University Health Science Center, Biosciences and Technology, Houston, TX, 77030, United States. Electronic address: jhurdle@tamu.edu.

Anaerobe ; 61: 102129, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31760080

Assuntos

Alquil e Aril Transferases/antagonistas & inibidores; Alquil e Aril Transferases/metabolismo; Antibacterianos/farmacologia; Clostridioides difficile/efeitos dos fármacos; Clostridioides difficile/enzimologia; Infecções por Clostridium/microbiologia; Peptidoglicano/biossíntese; Infecções por Clostridium/tratamento farmacológico; Ativação Enzimática/efeitos dos fármacos; Inibidores Enzimáticos/farmacologia; Regulação Bacteriana da Expressão Gênica; Humanos; Esporos Bacterianos/efeitos dos fármacos; Esporos Bacterianos/enzimologia

Palavras-chave

Antibiotic drug-targets; Heat-resistant spore cortex; Mur ligases; Peptidoglycan

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptidoglicano / Clostridioides difficile / Infecções por Clostridium / Alquil e Aril Transferases / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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