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Role of MicroRNAs in the Regulation of Redox-Dependent Processes.
Kalinina, E V; Ivanova-Radkevich, V I; Chernov, N N.
Afiliação
  • Kalinina EV; Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russia. kalinina-ev@rudn.ru.
  • Ivanova-Radkevich VI; Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russia.
  • Chernov NN; Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russia.
Biochemistry (Mosc) ; 84(11): 1233-1246, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31760914
Cellular redox homeostasis involves a combination of redox processes and corresponding regulatory systems and represents an important factor ensuring cell viability. Redox-dependent regulation of cellular processes is a multi-level system including not only proteins and enzyme complexes, but also non-coding RNAs, among which an important role belongs to microRNAs. The review focuses on the involvement of miRNAs in the redox-dependent regulation of both ROS (reactive oxygen species)-generating enzymes and antioxidant enzymes with special emphasis on the effects of miRNAs on redox-dependent processes in tumor cells. The impact of ROS on the miRNA expression and the role of the ROS/miRNA feedback regulation in the cell redox state are discussed.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article