Early intravenous administration of tranexamic acid ameliorates intestinal barrier injury induced by neutrophil extracellular traps in a rat model of trauma/hemorrhagic shock.

Chu, Chengnan; Yang, Chao; Wang, Xinyu; Xie, Tian; Sun, Shilong; Liu, Baochen; Wang, Kai; Duan, Zehua; Ding, Weiwei; Li, Jieshou

Chu, Chengnan; Yang, Chao; Wang, Xinyu; Xie, Tian; Sun, Shilong; Liu, Baochen; Wang, Kai; Duan, Zehua; Ding, Weiwei; Li, Jieshou.

Afiliação

Chu C; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Yang C; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Wang X; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Xie T; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Sun S; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Liu B; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Wang K; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Duan Z; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Ding W; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. Electronic address: dingwei_nju@hotmail.com.
Li J; Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.

Surgery ; 167(2): 340-351, 2020 02.

Article em En | MEDLINE | ID: mdl-31761396

Assuntos

Antifibrinolíticos/administração & dosagem; Armadilhas Extracelulares/efeitos dos fármacos; Enteropatias/prevenção & controle; Mucosa Intestinal/efeitos dos fármacos; Choque Hemorrágico/complicações; Ácido Tranexâmico/administração & dosagem; Animais; Células Cultivadas; Avaliação Pré-Clínica de Medicamentos; Humanos; Enteropatias/etiologia; Mucosa Intestinal/lesões; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Neutrófilos/efeitos dos fármacos; Distribuição Aleatória; Ratos Sprague-Dawley

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Choque Hemorrágico / Ácido Tranexâmico / Armadilhas Extracelulares / Enteropatias / Mucosa Intestinal / Antifibrinolíticos Tipo de estudo: Clinical_trials / Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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