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Latest advances in aging research and drug discovery.
Bakula, Daniela; Ablasser, Andrea; Aguzzi, Adriano; Antebi, Adam; Barzilai, Nir; Bittner, Martin-Immanuel; Jensen, Martin Borch; Calkhoven, Cornelis F; Chen, Danica; Grey, Aubrey D N J de; Feige, Jerome N; Georgievskaya, Anastasia; Gladyshev, Vadim N; Golato, Tyler; Gudkov, Andrei V; Hoppe, Thorsten; Kaeberlein, Matt; Katajisto, Pekka; Kennedy, Brian K; Lal, Unmesh; Martin-Villalba, Ana; Moskalev, Alexey A; Ozerov, Ivan; Petr, Michael A; Rubinsztein, David C; Tyshkovskiy, Alexander; Vanhaelen, Quentin; Zhavoronkov, Alex; Scheibye-Knudsen, Morten.
Afiliação
  • Bakula D; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Ablasser A; Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Aguzzi A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
  • Antebi A; Max Planck Institute for Biology of Ageing, Cologne, Germany.
  • Barzilai N; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
  • Bittner MI; Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Jensen MB; Arctoris, Oxford, UK.
  • Calkhoven CF; Gordian Biotechnology, San Francisco, CA 94107, USA.
  • Chen D; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, AD Groningen, The Netherlands.
  • Grey ADNJ; Program in Metabolic Biology, Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.
  • Feige JN; SENS Research Foundation, Mountain View, CA 94041, USA.
  • Georgievskaya A; Nestlé Research, EPFL Innovation Park, Lausanne, Switzerland.
  • Gladyshev VN; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Golato T; Haut.AI, Tallinn, Estonia.
  • Gudkov AV; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Hoppe T; Molecule, Basel, Switzerland.
  • Kaeberlein M; Roswell Park Comprehensive Cancer Center and Genome Protection, Inc., Buffalo, NY 14203, USA.
  • Katajisto P; Institute for Genetics and CECAD Research Center, University of Cologne, Cologne, Germany.
  • Kennedy BK; Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98195, USA.
  • Lal U; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
  • Martin-Villalba A; Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.
  • Moskalev AA; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
  • Ozerov I; Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore.
  • Petr MA; Centre for Healthy Ageing, National University Healthy System, Singapore.
  • Reason; Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Rubinsztein DC; Frost and Sullivan, Frankfurt am Main, Germany.
  • Tyshkovskiy A; Molecular Neurobiology, German Cancer Research Center, Heidelberg, Germany.
  • Vanhaelen Q; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
  • Zhavoronkov A; Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia.
  • Scheibye-Knudsen M; Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
Aging (Albany NY) ; 11(22): 9971-9981, 2019 11 21.
Article em En | MEDLINE | ID: mdl-31770722
ABSTRACT
An increasing aging population poses a significant challenge to societies worldwide. A better understanding of the molecular, cellular, organ, tissue, physiological, psychological, and even sociological changes that occur with aging is needed in order to treat age-associated diseases. The field of aging research is rapidly expanding with multiple advances transpiring in many previously disconnected areas. Several major pharmaceutical, biotechnology, and consumer companies made aging research a priority and are building internal expertise, integrating aging research into traditional business models and exploring new go-to-market strategies. Many of these efforts are spearheaded by the latest advances in artificial intelligence, namely deep learning, including generative and reinforcement learning. To facilitate these trends, the Center for Healthy Aging at the University of Copenhagen and Insilico Medicine are building a community of Key Opinion Leaders (KOLs) in these areas and launched the annual conference series titled "Aging Research and Drug Discovery (ARDD)" held in the capital of the pharmaceutical industry, Basel, Switzerland (www.agingpharma.org). This ARDD collection contains summaries from the 6th annual meeting that explored aging mechanisms and new interventions in age-associated diseases. The 7th annual ARDD exhibition will transpire 2nd-4th of September, 2020, in Basel.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pesquisa / Envelhecimento / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pesquisa / Envelhecimento / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article