Apigenin, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling.

Li, Yue; Cheng, Xiaoyan; Chen, Changlan; Huijuan, Wu; Zhao, Hong; Liu, Wei; Xiang, Zheng; Wang, Qi

Li, Yue; Cheng, Xiaoyan; Chen, Changlan; Huijuan, Wu; Zhao, Hong; Liu, Wei; Xiang, Zheng; Wang, Qi.

Afiliação

Li Y; Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China. Electronic address: liyuedl04@ccmu.edu.cn.
Cheng X; Beijing Center for Physical and Chemical Analysis, Beijing 100093, China. Electronic address: shmilycxy333@163.com.
Chen C; School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China. Electronic address: chenchanglanbio@aliyun.com.
Huijuan W; Beijing Center for Physical and Chemical Analysis, Beijing 100093, China. Electronic address: wuhuijuan@beijinglab.com.cn.
Zhao H; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China. Electronic address: sally2004@126.com.
Liu W; School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China. Electronic address: liuweiolina@163.com.
Xiang Z; School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China. Electronic address: rainbowaftersnow@hotmail.com.
Wang Q; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China. Electronic address: wangqidl04@ccmu.edu.cn.

Pathol Res Pract ; 216(1): 152701, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31780054

Assuntos

Apigenina/farmacologia; Carcinoma Hepatocelular/metabolismo; Quinase 4 Dependente de Ciclina/efeitos dos fármacos; Neoplasias Hepáticas/metabolismo; Apigenina/metabolismo; Apoptose/efeitos dos fármacos; Carcinoma Hepatocelular/tratamento farmacológico; Carcinoma Hepatocelular/patologia; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/fisiologia; Regulação para Baixo/efeitos dos fármacos; Flavonoides/farmacologia; Humanos; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/patologia; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Proteínas Quinases p38 Ativadas por Mitógeno/efeitos dos fármacos

Palavras-chave

Apigenin; Cell cycle; CyclinD1/CDK4 regulation; P. villosa juss; p38 MAPK-p21 signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Apigenina / Quinase 4 Dependente de Ciclina / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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