Enhanced alleviation of aGVHD by TGF-ß1-modified mesenchymal stem cells in mice through shifting M&#934; into M2 phenotype and promoting the differentiation of Treg cells.

Wu, Ran; Liu, Chuanxu; Deng, Xiaohui; Chen, Linjun; Hao, Siguo; Ma, Liyuan

Enhanced alleviation of aGVHD by TGF-ß1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Wu, Ran; Liu, Chuanxu; Deng, Xiaohui; Chen, Linjun; Hao, Siguo; Ma, Liyuan.

Afiliação

Wu R; Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu C; Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Deng X; Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen L; Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao S; Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ma L; Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

J Cell Mol Med ; 24(2): 1684-1699, 2020 01.

Article em En | MEDLINE | ID: mdl-31782262

Assuntos

Diferenciação Celular; Doença Enxerto-Hospedeiro/imunologia; Macrófagos/patologia; Células-Tronco Mesenquimais/metabolismo; Linfócitos T Reguladores/imunologia; Fator de Crescimento Transformador beta1/metabolismo; Doença Aguda; Animais; Medula Óssea/patologia; Polaridade Celular; Forma Celular; Modelos Animais de Doenças; Feminino; Doença Enxerto-Hospedeiro/patologia; Proteínas de Fluorescência Verde/metabolismo; Imunofenotipagem; Terapia de Imunossupressão; Masculino; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Fenótipo; Análise de Sobrevida

Palavras-chave

allogeneic haematopoietic stem cell transplantation; graft-versus-host disease; mesenchymal stem cell; transforming growth factor-ß1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Linfócitos T Reguladores / Fator de Crescimento Transformador beta1 / Células-Tronco Mesenquimais / Doença Enxerto-Hospedeiro / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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