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ALK-negative anaplastic large cell lymphoma with "Hodgkin-like" cytomorphology and nuclear expression of PAX5.
Fratoni, Stefano; Niscola, Pasquale; Zhao, Xiangfeng Frank; Larocca, Luigi Maria; Capalbo, Anna; Fabbretti, Maria; Bernardini, Laura; Abruzzese, Elisabetta.
Afiliação
  • Fratoni S; Department of Surgical-Pathology/Hematopathology, Saint'Eugenio Hospital, Rome, Italy.
  • Niscola P; Hematology Unit, Saint' Eugenio Hospital, Rome, Italy. Electronic address: pniscola@gmail.com.
  • Zhao XF; Phoenix VA Healthcare System Pathology & Laboratory Medicine Service, Department of Pathology University of Arizona College of Medicine, Phoenix, Arizona, USA.
  • Larocca LM; Department of Surgical-Pathology, Catholic University, Rome, Italy.
  • Capalbo A; Cytogenetics Unit, Casa Sollievo della Sofferenza IRCCS Foundation, San Giovanni Rotondo, Italy.
  • Fabbretti M; Department of Surgical-Pathology, Catholic University, Rome, Italy.
  • Bernardini L; CSS-Mendel Institute, Rome, Italy.
  • Abruzzese E; Hematology Unit, Saint' Eugenio Hospital, Rome, Italy.
Pathol Res Pract ; 216(2): 152724, 2020 Feb.
Article em En | MEDLINE | ID: mdl-31784094
ABSTRACT
Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking "Hodgkin-like" cytomorphology and a very uncommon nuclear expression of PAX5.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes / Fator de Transcrição PAX5 Limite: Aged80 / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes / Fator de Transcrição PAX5 Limite: Aged80 / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article