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Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.
Lercher, Alexander; Bhattacharya, Anannya; Popa, Alexandra M; Caldera, Michael; Schlapansky, Moritz F; Baazim, Hatoon; Agerer, Benedikt; Gürtl, Bettina; Kosack, Lindsay; Májek, Peter; Brunner, Julia S; Vitko, Dijana; Pinter, Theresa; Genger, Jakob-Wendelin; Orlova, Anna; Pikor, Natalia; Reil, Daniela; Ozsvár-Kozma, Maria; Kalinke, Ulrich; Ludewig, Burkhard; Moriggl, Richard; Bennett, Keiryn L; Menche, Jörg; Cheng, Paul N; Schabbauer, Gernot; Trauner, Michael; Klavins, Kristaps; Bergthaler, Andreas.
Afiliação
  • Lercher A; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Bhattacharya A; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Popa AM; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Caldera M; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Schlapansky MF; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Baazim H; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Agerer B; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Gürtl B; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Kosack L; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Májek P; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Brunner JS; Department of Thrombosis Research and Vascular Biology, Medical University of Vienna, 1090 Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090 Vienna, Austria.
  • Vitko D; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria; Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Pinter T; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
  • Genger JW; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
  • Pikor N; Institute of Immunobiology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
  • Reil D; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Ozsvár-Kozma M; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria; Department for Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
  • Kalinke U; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, 30625 Hannover, Germany.
  • Ludewig B; Institute of Immunobiology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
  • Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria; Medical University of Vienna, 1090 Vienna, Austria.
  • Bennett KL; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Menche J; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Cheng PN; Bio-Cancer Treatment International Limited, Hong Kong, China.
  • Schabbauer G; Department of Thrombosis Research and Vascular Biology, Medical University of Vienna, 1090 Vienna, Austria; Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis, 1090 Vienna, Austria.
  • Trauner M; Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
  • Klavins K; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria.
  • Bergthaler A; CeMM Research Center for Molecular Medicine or the Austrian Academy of Sciences, Lazarettgasse 14 AKH BT25.3, 1090 Vienna, Austria. Electronic address: abergthaler@cemm.oeaw.ac.at.
Immunity ; 51(6): 1074-1087.e9, 2019 12 17.
Article em En | MEDLINE | ID: mdl-31784108
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Interferon Tipo I / Linfócitos T CD8-Positivos / Receptor de Interferon alfa e beta / Fígado / Vírus da Coriomeningite Linfocítica Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Interferon Tipo I / Linfócitos T CD8-Positivos / Receptor de Interferon alfa e beta / Fígado / Vírus da Coriomeningite Linfocítica Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article