A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations.

Chiang, Ason C-Y; McCartney, Eleanor; O'Farrell, Patrick H; Ma, Hansong

Chiang, Ason C-Y; McCartney, Eleanor; O'Farrell, Patrick H; Ma, Hansong.

Afiliação

Chiang AC; Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
McCartney E; Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
O'Farrell PH; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: ofarrell@cgl.ucsf.edu.
Ma H; Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. Electronic address: hm555@cam.ac.uk.

Curr Biol ; 29(24): 4330-4336.e3, 2019 12 16.

Article em En | MEDLINE | ID: mdl-31786061

Assuntos

DNA Polimerase gama/metabolismo; DNA Mitocondrial/genética; Genoma Mitocondrial/genética; Animais; DNA Polimerase gama/genética; Proteínas de Drosophila/genética; Drosophila melanogaster/genética; Evolução Molecular; Mitocôndrias/genética; Mutação; Seleção Genética/genética

Palavras-chave

mito-nuclear interaction; mitochondrial DNA heteroplasmy; mtDNA competition; mtDNA polymerase gamma; mtDNA transmission and inheritance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Genoma Mitocondrial / DNA Polimerase gama Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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