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Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors.
Lei, Hao; Fan, Shu; Zhang, Hao; Liu, Yan-Jie; Hei, Yuan-Yuan; Zhang, Jun-Jie; Zheng, A-Qun; Xin, Minhang; Zhang, San-Qi.
Afiliação
  • Lei H; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Fan S; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Zhang H; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Liu YJ; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Hei YY; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Zhang JJ; School of Science, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
  • Zheng AQ; School of Science, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
  • Xin M; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China. Electronic address: xmhcpu@163.com.
  • Zhang SQ; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China. Electronic address: sqzhang@xjtu.edu.cn.
Eur J Med Chem ; 186: 111888, 2020 Jan 15.
Article em En | MEDLINE | ID: mdl-31787359
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Purinas / Inibidores de Proteínas Quinases / Descoberta de Drogas / Compostos Heterocíclicos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Purinas / Inibidores de Proteínas Quinases / Descoberta de Drogas / Compostos Heterocíclicos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article