Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their Aß-aggregation inhibitory activity.

Akiba, Megumi; Kinoshita, Kaoru; Kino, Yoshihiro; Sato, Jun-Ichi; Koyama, Kiyotaka

Akiba, Megumi; Kinoshita, Kaoru; Kino, Yoshihiro; Sato, Jun-Ichi; Koyama, Kiyotaka.

Afiliação

Akiba M; Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-552-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
Kinoshita K; Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-552-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
Kino Y; Department of Bioinformatics, Meiji Pharmaceutical University, 2-552-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
Sato JI; Department of Bioinformatics, Meiji Pharmaceutical University, 2-552-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
Koyama K; Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-552-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan. Electronic address: kiyotaka@my-pharm.ac.jp.

Bioorg Med Chem Lett ; 30(2): 126808, 2020 01 15.

Article em En | MEDLINE | ID: mdl-31791817

Assuntos

Peptídeos beta-Amiloides/antagonistas & inibidores; Basidiomycota/química; Resorcinóis/química; Terpenos/química; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/metabolismo; Basidiomycota/metabolismo; Humanos; Espectroscopia de Ressonância Magnética; Espectrometria de Massas; Conformação Molecular; Resorcinóis/metabolismo; Terpenos/metabolismo

Palavras-chave

Albatrellus yasudae; Alzheimer's disease (AD); Amyloid ß aggregation; Meroterpenoid; Mushroom; Thioflavin T

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resorcinóis / Terpenos / Basidiomycota / Peptídeos beta-Amiloides Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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