PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response.

Hiramatsu, Nobuhiko; Chiang, Karen; Aivati, Cathrine; Rodvold, Jeffrey J; Lee, Ji-Min; Han, Jaeseok; Chea, Leon; Zanetti, Maurizio; Koo, Edward H; Lin, Jonathan H

Hiramatsu, Nobuhiko; Chiang, Karen; Aivati, Cathrine; Rodvold, Jeffrey J; Lee, Ji-Min; Han, Jaeseok; Chea, Leon; Zanetti, Maurizio; Koo, Edward H; Lin, Jonathan H.

Afiliação

Hiramatsu N; Department of Pathology, University of California San Diego, La Jolla, California 92093-0612.
Chiang K; Department of Pathology, University of California San Diego, La Jolla, California 92093-0612; Department of Neurosciences, University of California San Diego, La Jolla, California 92093-0612.
Aivati C; Department of Pathology, University of California San Diego, La Jolla, California 92093-0612.
Rodvold JJ; Moores Cancer Center, University of California San Diego, La Jolla, California 92093-0612.
Lee JM; Soonchunhyang Institute of Med-bio Science, Soonchunhyang University, Asan 31151, Korea.
Han J; Soonchunhyang Institute of Med-bio Science, Soonchunhyang University, Asan 31151, Korea.
Chea L; Department of Pathology, Stanford University, Stanford, California 94304.
Zanetti M; Moores Cancer Center, University of California San Diego, La Jolla, California 92093-0612.
Koo EH; Department of Neurosciences, University of California San Diego, La Jolla, California 92093-0612; Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117549 Singapore.
Lin JH; Department of Pathology, University of California San Diego, La Jolla, California 92093-0612; Department of Pathology, Stanford University, Stanford, California 94304; Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304. Electronic address: jlinn@stanford.edu.

J Biol Chem ; 295(1): 237-249, 2020 01 03.

Article em En | MEDLINE | ID: mdl-31792031

Assuntos

Trifosfato de Adenosina/metabolismo; MicroRNAs/metabolismo; Resposta a Proteínas não Dobradas; eIF-2 Quinase/metabolismo; Fator 4 Ativador da Transcrição/genética; Fator 4 Ativador da Transcrição/metabolismo; Apoptose; Creatina Quinase Forma BB/genética; Creatina Quinase Forma BB/metabolismo; Células HEK293; Células HeLa; Homeostase; Humanos; MicroRNAs/genética; eIF-2 Quinase/genética

Palavras-chave

ATP; F1F0-ATPase; PKR-like endoplasmic reticulum kinase (PERK); activating transcription factor-4 (ATF-4); creatine kinase B (CKB); endoplasmic reticulum (ER); endoplasmic reticulum stress (ER stress); fluorescence resonance energy transfer (FRET); microRNA (miRNA); stress response; translation; translation control; unfolded protein response (UPR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / EIF-2 Quinase / MicroRNAs / Resposta a Proteínas não Dobradas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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