Impact of noise exposure on the circadian clock in the auditory system.
J Acoust Soc Am
; 146(5): 3960, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31795664
ABSTRACT
Circadian rhythms control the timing of all bodily functions, and misalignment in the rhythms can cause various diseases. Moreover, circadian rhythms are highly conserved and are regulated by a transcriptional-translational feedback loop of circadian genes that has a periodicity of approximately 24 h. The cochlea and the inferior colliculus (IC) have been shown to possess an autonomous and self-sustained circadian system as demonstrated by recording, in real time, the bioluminescence from PERIOD2LUCIFERASE (PER2LUC) mice. The cochlea and IC both express the core clock genes, Per1, Per2, Bmal1, and Rev-Erbα, where RNA abundance is rhythmically distributed with a 24 h cycle. Noise exposure alters clock gene expression in the cochlea and the IC after noise stimulation, although in different ways. These findings highlight the importance of circadian responses in the cochlea and the IC and emphasize the importance of circadian mechanisms for understanding the differences in central and peripheral auditory function and the subsequent molecular changes that occur after daytime (inactive phase) or nighttime (active phase) noise trauma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colículos Inferiores
/
Cóclea
/
Peptídeos e Proteínas de Sinalização do Ritmo Circadiano
/
Relógios Circadianos
/
Ruído
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article