MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.

Aryal, Sandeep; Anand, Deepti; Hernandez, Francisco G; Weatherbee, Bailey A T; Huang, Hongzhan; Reddy, Ashok P; Wilmarth, Phillip A; David, Larry L; Lachke, Salil A

Aryal, Sandeep; Anand, Deepti; Hernandez, Francisco G; Weatherbee, Bailey A T; Huang, Hongzhan; Reddy, Ashok P; Wilmarth, Phillip A; David, Larry L; Lachke, Salil A.

Afiliação

Aryal S; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Anand D; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Hernandez FG; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Weatherbee BAT; Department of Biological Sciences, University of Delaware, 105 The Green, Delaware Avenue, 236 Wolf Hall, Newark, DE, USA.
Huang H; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, 19716, USA.
Reddy AP; Proteomics Shared Resource, Oregon Health and Science University, Portland, OR, 97239, USA.
Wilmarth PA; Proteomics Shared Resource, Oregon Health and Science University, Portland, OR, 97239, USA.
David LL; Proteomics Shared Resource, Oregon Health and Science University, Portland, OR, 97239, USA.
Lachke SA; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, 97239, USA.

Hum Genet ; 139(2): 151-184, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31797049

Assuntos

Biomarcadores/metabolismo; Catarata/metabolismo; Simulação por Computador; Proteínas do Olho/metabolismo; Cristalino/metabolismo; Proteoma/metabolismo; Espectrometria de Massas em Tandem/métodos; Animais; Catarata/genética; Catarata/patologia; Biologia Computacional; Proteínas do Olho/genética; Perfilação da Expressão Gênica; Humanos; Cristalino/embriologia; Camundongos; Camundongos Endogâmicos C57BL; Proteoma/análise; Transcriptoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catarata / Simulação por Computador / Biomarcadores / Proteoma / Proteínas do Olho / Espectrometria de Massas em Tandem / Cristalino Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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