Leukocyte telomere length in patients with myotonic dystrophy type I: a pilot study.
Ann Clin Transl Neurol
; 7(1): 126-131, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31808320
ABSTRACT
Myotonic dystrophy type I (DM1) is an autosomal dominant disease of which clinical manifestations resemble premature aging. We evaluated the contribution of telomere length in pathogenesis in 361 DM1 patients (12 with serial measurements) and 223 unaffected relative controls using qPCR assay. While no differences in baseline leukocyte relative telomere length (RTL) was noted, the data suggested an accelerated RTL attrition in DM1 (discovery cohort T/S change/year = -0.013 in DM1 vs. -0.005 in controls, P = 0.04); similar trend was noted in validation cohort. Further investigations are needed to examine the role of TL in the pathophysiology of DM1.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encurtamento do Telômero
/
Leucócitos
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Distrofia Miotônica
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article