Nitrenium Salts in Lewis Acid Catalysis.
Angew Chem Int Ed Engl
; 59(7): 2715-2719, 2020 Feb 10.
Article
em En
| MEDLINE
| ID: mdl-31808974
ABSTRACT
Molecular compounds featuring nitrogen atoms are typically regarded as Lewis bases and are extensively employed as donor ligands in coordination chemistry or as nucleophiles in organic chemistry. By contrast, electrophilic nitrogen-containing compounds are much rarer. Nitrenium cations are a new family of nitrogen-based Lewis acids, the reactivity of which remains largely unexplored. In this work, nitrenium ions are explored as catalysts in five organic transformations. These reactions are the first examples of Lewis acid catalysis employing nitrogen as the site of substrate activation. Moreover, these compounds are readily accessed from commercially available reagents and exhibit remarkable stability toward moisture, allowing for benchtop transformations without the need to pretreat solvents.
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MEDLINE
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En
Ano de publicação:
2020
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Article