Altered m<sup>6</sup>A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.

Gokhale, Nandan S; McIntyre, Alexa B R; Mattocks, Melissa D; Holley, Christopher L; Lazear, Helen M; Mason, Christopher E; Horner, Stacy M

Altered m⁶A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.

Gokhale, Nandan S; McIntyre, Alexa B R; Mattocks, Melissa D; Holley, Christopher L; Lazear, Helen M; Mason, Christopher E; Horner, Stacy M.

Afiliação

Gokhale NS; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27705, USA.
McIntyre ABR; Department of Physiology and Biophysics and the Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10065, USA.
Mattocks MD; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Holley CL; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27705, USA; Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA.
Lazear HM; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Mason CE; Department of Physiology and Biophysics and the Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; The HRH Prince Alwaleed Bin Talal Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; The WorldQuant Initia
Horner SM; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27705, USA; Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA. Electronic address: stacy.horner@duke.edu.

Mol Cell ; 77(3): 542-555.e8, 2020 02 06.

Article em En | MEDLINE | ID: mdl-31810760

Assuntos

Adenosina/análogos & derivados; Infecções por Flaviviridae/genética; RNA Mensageiro/genética; Adenosina/genética; Linhagem Celular; Dengue/virologia; Vírus da Dengue/genética; Flaviviridae/genética; Hepacivirus/genética; Hepatite C/virologia; Interações Hospedeiro-Patógeno/genética; Humanos; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Replicação Viral/genética; Zika virus/genética; Infecção por Zika virus/genética

Palavras-chave

CIRBP; ER stress; Flaviviridae; RIOK3; RNA modification; epitranscriptome; innate immunity; m(6)A; signaling; viral infection

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Adenosina / Infecções por Flaviviridae Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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