Essential functions of Runx/Cbfß in gut conventional dendritic cells for priming Rorγt+ T cells.
Life Sci Alliance
; 3(1)2020 01.
Article
em En
| MEDLINE
| ID: mdl-31818882
ABSTRACT
Acquired immune responses are initiated by activation of CD4+ helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). DCs instruct Th-cell polarization program into specific effector Th subset, which will dictate the type of immune responses. Hence, it is important to unravel how differentiation and/or activation of DC are linked with Th-cell-intrinsic mechanism that directs differentiation toward a specific effector Th subset. Here, we show that loss of Runx/Cbfß transcription factors complexes during DC development leads to loss of CD103+CD11b+ cDC2s and alters characteristics of CD103-CD11b+ cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt+ Th17 cells and type 3 Rorγt+ regulatory T cells. We also show that a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. These findings reveal that Runx/Cbfß complexes play crucial and complementary roles in cDCs and Th cells to shape converging type 3 immune responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Linfócitos T Reguladores
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Subunidade alfa 2 de Fator de Ligação ao Core
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Subunidade alfa 3 de Fator de Ligação ao Core
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Subunidade beta de Fator de Ligação ao Core
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Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares
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Células Th17
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Mucosa Intestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article