Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.

Zhang, Wei-Wei; Zheng, Rong-Hua; Bai, Feng; Sturdivant, Katelyn; Wang, Ning-Ping; James, Erskine A; Bose, Himangshu S; Zhao, Zhi-Qing

Zhang, Wei-Wei; Zheng, Rong-Hua; Bai, Feng; Sturdivant, Katelyn; Wang, Ning-Ping; James, Erskine A; Bose, Himangshu S; Zhao, Zhi-Qing.

Afiliação

Zhang WW; Department of Basic Biomedical Sciences, Mercer University School of Medicine, Savannah, GA, USA.
Zheng RH; Department of Anesthesiology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Bai F; Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi, China.
Sturdivant K; Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi, China.
Wang NP; Department of Basic Biomedical Sciences, Mercer University School of Medicine, Savannah, GA, USA.
James EA; Department of Basic Biomedical Sciences, Mercer University School of Medicine, Savannah, GA, USA.
Bose HS; Department of Internal Medicine, Navicent Health, Macon, GA, USA.
Zhao ZQ; Department of Basic Biomedical Sciences, Mercer University School of Medicine, Savannah, GA, USA.

Mol Biol Rep ; 47(2): 1207-1222, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31820314

Assuntos

Angiotensina II/metabolismo; Cardiomegalia/etiologia; Cardiomegalia/metabolismo; Cardiomiopatias/etiologia; Cardiomiopatias/metabolismo; Citocromo P-450 CYP11B2/metabolismo; Fosfoproteínas/genética; Glândulas Suprarrenais/metabolismo; Animais; Biomarcadores; Biópsia; Cardiomegalia/patologia; Cardiomiopatias/patologia; Colágeno/metabolismo; Modelos Animais de Doenças; Suscetibilidade a Doenças; Fibrose; Imuno-Histoquímica; Macrófagos/imunologia; Macrófagos/metabolismo; Masculino; Modelos Biológicos; Miocárdio/metabolismo; Miocárdio/patologia; Miofibroblastos/metabolismo; Ratos; Receptor Tipo 1 de Angiotensina/metabolismo; Transdução de Sinais; Proteína Smad2/metabolismo; Proteína Smad3/metabolismo

Palavras-chave

AT1 receptor; Aldosterone synthase; Angiotensin II; Cardiac fibrosis; Cardiac hypertrophy; Steroidogenic acute regulatory protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Angiotensina II / Cardiomegalia / Citocromo P-450 CYP11B2 / Cardiomiopatias Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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