The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.
J Int Neuropsychol Soc
; 26(6): 596-606, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-31822309
ABSTRACT
OBJECTIVES:
The present study explored relationships among personality, Alzheimer's disease (AD) biomarkers, and dementia by addressing the following questions (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion?METHODS:
Both self- and informant ratings of personality were obtained in a large well-characterized longitudinal sample of cognitively normal older adults (N = 436) and individuals with early-stage dementia (N = 74). Biomarkers included amyloid imaging, hippocampal volume, cerebral spinal fluid (CSF) Aß42, and CSF tau.RESULTS:
Higher neuroticism, lower conscientiousness, along with all four biomarkers strongly discriminated cognitively normal controls from early-stage AD individuals. The direct effects of neuroticism and conscientiousness were only mediated by hippocampal volume. Conscientiousness along with all biomarkers predicted conversion from healthy aging to early-stage AD; however, none of the biomarkers mediated the relationship between conscientiousness and conversion. Conscientiousness predicted conversion as strongly as the biomarkers, with the exception of hippocampal volume.CONCLUSIONS:
Conscientiousness and to a lesser extent neuroticism serve as important independent behavioral markers for AD risk.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Personalidade
/
Biomarcadores
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Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article