Berberine attenuated the cytotoxicity induced by t-BHP via inhibiting oxidative stress and mitochondria dysfunction in PC-12 cells.

Li, Zhengmao; Jiang, Ting; Lu, Qi; Xu, Ke; He, Jianping; Xie, Lei; Chen, Zaifeng; Zheng, Zhilong; Ye, Luxia; Xu, Kebin; Zhang, Hongyu; Hu, Aiping

Li, Zhengmao; Jiang, Ting; Lu, Qi; Xu, Ke; He, Jianping; Xie, Lei; Chen, Zaifeng; Zheng, Zhilong; Ye, Luxia; Xu, Kebin; Zhang, Hongyu; Hu, Aiping.

Afiliação

Li Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jiang T; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lu Q; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xu K; Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang, China.
He J; Department of Pharmacy, Shaoxing No. 2 Hospital, Shaoxing, Zhejiang, China.
Xie L; Department of Orthopaedics, Shaoxing No. 2 Hospital, Shaoxing, Zhejiang, China.
Chen Z; Department of Neurosurgery, Cixi People's Hospital, Wenzhou Medical Uinversity, Ninbo, Zhejiang, China.
Zheng Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ye L; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xu K; Department of Pharmacy, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Zhang H; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. hyzhang@wmu.edu.cn.
Hu A; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. hap@wmu.edu.cn.

Cell Mol Neurobiol ; 40(4): 587-602, 2020 May.

Article em En | MEDLINE | ID: mdl-31828466

Assuntos

Berberina/farmacologia; Mitocôndrias/patologia; Estresse Oxidativo/efeitos dos fármacos; terc-Butil Hidroperóxido/toxicidade; Animais; Morte Celular/efeitos dos fármacos; Cromonas/farmacologia; Citocromos c/metabolismo; Lisossomos/efeitos dos fármacos; Lisossomos/metabolismo; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Proteínas Associadas aos Microtúbulos/metabolismo; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Mitofagia/efeitos dos fármacos; Morfolinas/farmacologia; Células PC12; Ratos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Berberine (BBR); Mitophagy; Neurotoxicity Analysis of variance; Oxidative stress; PI3K/AKT/mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Berberina / Estresse Oxidativo / Terc-Butil Hidroperóxido / Mitocôndrias Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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