The antioxidant and immunomodulatory compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole attenuates depression-like behavior and cognitive impairment developed in a mouse model of breast tumor.

Casaril, Angela Maria; Domingues, Micaela; Bampi, Suely Ribeiro; Lourenço, Darling de Andrade; Smaniotto, Thiago Ângelo; Segatto, Natália; Vieira, Beatriz; Seixas, Fabiana K; Collares, Tiago; Lenardão, Eder João; Savegnago, Lucielli

Casaril, Angela Maria; Domingues, Micaela; Bampi, Suely Ribeiro; Lourenço, Darling de Andrade; Smaniotto, Thiago Ângelo; Segatto, Natália; Vieira, Beatriz; Seixas, Fabiana K; Collares, Tiago; Lenardão, Eder João; Savegnago, Lucielli.

Afiliação

Casaril AM; Technological Development Center, Division of Biotechnology, Neurobiotechology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Domingues M; Technological Development Center, Division of Biotechnology, Neurobiotechology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Bampi SR; Technological Development Center, Division of Biotechnology, Neurobiotechology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Lourenço DA; Technological Development Center, Division of Biotechnology, Neurobiotechology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Smaniotto TÂ; Technological Development Center, Division of Biotechnology, Neurobiotechology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil.
Segatto N; Technological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group and Functional Genomics Laboratory, Federal University of Pelotas, Pelotas, RS, Brazil.
Vieira B; Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, Brazil.
Seixas FK; Technological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group and Functional Genomics Laboratory, Federal University of Pelotas, Pelotas, RS, Brazil.
Collares T; Technological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group and Functional Genomics Laboratory, Federal University of Pelotas, Pelotas, RS, Brazil.
Lenardão EJ; Center of Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, Brazil.
Savegnago L; Technological Development Center, Division of Biotechnology, Neurobiotechology Research Group, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br.

Brain Behav Immun ; 84: 229-241, 2020 02.

Article em En | MEDLINE | ID: mdl-31837417

Assuntos

Antioxidantes; Neoplasias da Mama; Disfunção Cognitiva; Depressão; Indóis; Animais; Antioxidantes/farmacologia; Antioxidantes/uso terapêutico; Neoplasias da Mama/complicações; Neoplasias da Mama/tratamento farmacológico; Disfunção Cognitiva/tratamento farmacológico; Depressão/tratamento farmacológico; Depressão/etiologia; Modelos Animais de Doenças; Feminino; Humanos; Indóis/farmacologia; Indóis/uso terapêutico; Camundongos; Camundongos Endogâmicos BALB C; Simulação de Acoplamento Molecular; Estresse Oxidativo/efeitos dos fármacos; Qualidade de Vida; Compostos de Selênio

Palavras-chave

Antioxidant; Cognition; Depression; Immunomodulatory; Organoselenium; Tumor-bearing mice

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Depressão / Disfunção Cognitiva / Indóis / Antioxidantes Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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